Comparative Hazards of Ocular Surface Disorders with IL-4/13 versus IL-13 Inhibitors in Atopic Dermatitis

Description

This dataset contains the supplementary materials associated with the study “Comparative Hazards of Ocular Surface Disorders with IL-4/13 versus IL-13 Inhibitors in Atopic Dermatitis: A TriNetX Database Study.” The materials include detailed coding definitions, additional analyses, and supporting figures that complement the main manuscript and provide transparency for the analytic methods and results.

Steps to reproduce

Data were derived from the TriNetX network database. Patients with atopic dermatitis were identified using standardized diagnosis codes and predefined inclusion and exclusion criteria. Exposure cohorts were defined based on treatment with IL-13 inhibitors and IL-4/13 inhibitors. Outcomes were ascertained using prespecified diagnostic and medication codes for ocular surface disorders and associated ophthalmic agents. Cohorts were balanced using propensity score matching based on demographic characteristics, comorbidities, lab values, and baseline medication use. Time-to-event analyses were conducted using Cox proportional hazards models to estimate hazard ratios with corresponding confidence intervals. Sensitivity, time-restricted, and agent-level analyses were performed to assess robustness of findings. All analyses were conducted within the TriNetX analytics platform using its built-in statistical workflows.

Institutions

• National Yang Ming Chiao Tung University

  Taiwan, Hsinchu

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