human Vim-DBS data of membrane potential
Description
The data protocols are from Milosevic et al. (2021) (L. Milosevic et al., “A theoretical framework for the site-specific and frequency-dependent neuronal effects of deep brain stimulation,” Brain Stimul, vol. 14, no. 4, pp. 807–821, 2021, doi: 10.1016/j.brs.2021.04.022.) The data were recorded from the thalamic ventral intermediate nucleus (Vim) in human patients receiving DBS for treating essential tremor. Microelectrodes were used to both deliver DBS and perform single-unit recordings. DBS was delivered using 100 µA and symmetric 0.3ms biphasic pulses (150µs cathodal followed by 150 µs anodal). In this work, we used the entire dataset of single-unit recordings of the neurons in the thalamic ventral intermediate nucleus (Vim) of essential tremor patients, during various DBS frequencies (5 to 200 Hz) in Vim. The single-unit recordings during {5, 10, 20, 30, 50, 100, and 200 Hz} Vim-DBS are of length {10, 5, 3, 2, 1, 5, and 2 s}, respectively; for each frequency of DBS, we did 5 to 8 recordings in different patients (total number of patients = 19). To obtain spikes from the single-unit recordings, we did offline analysis and spike template matching. For each single-unit recording, all the narrow stimulus artifacts were removed (0.5 ms from the onset of a DBS pulse). Then the recordings were high pass filtered (≥300 Hz) to better isolate the spikes, which were identified by the template matching using a principal component analysis method in Spike2 (Cambridge Electronic Design, UK).
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Institutions
- University of Toronto