OSI-027 and MRC-5 cells

Published: 22 August 2022| Version 1 | DOI: 10.17632/kzkph6c2hg.1
Contributor:
Hongxing Dang

Description

Hyperoxia promotes time-dependent cell proliferation and the differentiation of lung fibroblasts, as well as the activation of the mTOR signaling pathway. The dual mTORC1/2 inhibitor OSI-027 inhibits the proliferation and differentiation of MRC-5 cells under hyperoxia exposure and is expected to provide a new target for clinical intervention in hyperoxic pulmonary fibrosis.

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Categories

Mammalian Target of Rapamycin, Cell Proliferation, Pulmonary Fibrosis

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