Data for: Protective effect of intra-operative dexmedetomidine infusion combined with epidural blockade on postoperative analgesia and early cognitive dysfunction for elder patients after radical resection of colorectal cancer
Description
The purpose of this article was to investigate the efficacy of dexmedetomidine combined with epidural blockade on postoperative recovery of elder patients after radical resection of colorectal cancer. The design of this study was a prospective randomized controlled double-blind trial. This prospective study included a total of 96 elder patients underwent colorectal cancer radical resection during December 2018 to May 2019. Demographic data like age, gender, body mass index (BMI), and clinical data including ASA stage, pathological type and mean operative time were collected. The the mini-mental state examination (MMSE) score, Ramsay score and Visual Analogue Score (VAS) were all measured at 4h or 2 h, 12 h, 24 h and 48 h after surgery. Postoperative cognitive dysfunction (POCD) was defined as the difference between preoperative and postoperative mean MMSE score decline > 2 points. POCD incidence was recorded at 7 d postoperatively. The patient-controlled intravenous analgesia (PCIA) pump pressing time within 48 h, time for patients’ first out of bed activity, first anus exhaust time, hospital stay and complications within 3 months after surgery were also recorded. The follow-up lasted for 3 months. Our results showed that the combined group had the lowest VAS scores except for 48 h, and the lowest PCIA pressing times within 48 h. Within 24 h after surgery, the MMSE scores were significantly higher in the combined group than other groups. Within 12 h after surgery, the Ramsay scores were significantly higher in the combined group than the control and epidural blockade group. The first out of bed activity time and first anus exhaust time of the combined group were all significantly shorter than other groups. No significant difference was found in total postoperative complication rates and hospital stay time in all groups.