Plasma protein profiling in patients with neutropenia

Published: 25 November 2021| Version 1 | DOI: 10.17632/m4zv2p4tsy.1


Quantification of 249 plasma proteins in 53 adult neutropenia patients and 20 age- and sex-matched controls, as well as 10 children with neutropenia and 5 child controls. The log2-transformed Normalized Protein eXpression (NPX) unit is used for all values. For this reason, values from different proteins cannot be compared. Proteins with more than 50% missing values were excluded from the analysis. Missing values for 12 of the remaining 249 proteins were replaced with Limit of Detection (LOD) values. Missing values in the published data set are caused by samples being excluded from some of the panels due to technical issues. Please refer to the referenced published article for technical details, clinical information and interpretation: Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia (Sohlberg et al., Blood, 2021).


Steps to reproduce

Plasma samples from patients or healthy blood donors were frozen, thawed and analyzed using a Proximity Extension Assay (PEA) by Olink Proteomics AB, Uppsala, Sweden. Proteins were analyzed using three separate PEA panels.


Karolinska Institutet


Neutropenia, Natural Killer Cell