Metabolic classification for enzymatic reactions present in the ten Cancer-Hallmarks of Homo sapiens and Arabidopsis thalina
Description
When performing the identification and metabolic classification of the genes that code for proteins with exclusive catalytic activity involved in Cancer-Hallmarks genes (CHG) and cancer development for each species; 1297 genes for H. sapiens (SD3) and 609 genes for A. thaliana (SD4) were found.
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To infer the metabolic processes involved in Cancer-Hallmarks (CH) genes and in cancer development for each species, both genes lists, Cancer-Hallmarks for H. sapiens and orthologues candidates in A. thaliana, were selected. Those genes that code for proteins with exclusively catalytic activity in BioCyc: HumanCyc and AraCyc database were manually identified and classified according to the metabolic process in which they are involved. All the information was curated manually; for each reaction, taking into account the metabolic hierarchical classification of BioCyc, the corresponding System, Subsystem and metabolic Sub-Subsystem were assigned for each enzyme as well.