Auditory evaluation of infants born to COVID19 positive mothers

Published: 30 December 2021| Version 1 | DOI: 10.17632/mf794c4256.1
Sara Ghiselli


COVID-19 infection can cause a wide spectrum of symptoms. The audio-vestibular system can also be involved, but there is still debate about this so findings need to be considered carefully. Furthermore, mother to fetus intrauterine transmission of COVID-19 infection in pregnant women is controversial. Few studies are available about the audio-vestibular symptomatology of newborns with intrauterine COVID19 exposure. This dataset is the basis of a study who wants to investigate the possible correlation between the COVID19 gestational infection and hearing impairment onset in newborns. The involvement of hearing in COVID19 is verified so the timing and methodology of audiological evaluation of children can be planned. In this dataset were collected: personal data of children and mothers, results of newborn hearing screening and audiological evaluation of the children born to COVID19-infected mothers. Children personal data were: gender, age at the moment of newborn hearing screening and auditory evaluation test, birth weight, gestational age, type of delivery, Apgar score, breastfeeding type, risk factors for hearing loss (according to JCHI 2019), COVID19 infection informations (infection, symptomatology, use of drugs). Mother data collected were: maternal age, TORCH complex (Toxoplasmosis, Others, Rubella, Cytomegalovirus, Herpes simplex) infections, use of drugs and pathologies during pregnancy, COVID19 case history concerning gestational age of infection, symptomatology, use of drugs, number and result of the nasopharyngeal swabs, and serologic evaluation. Concerning newborn hearing screening data, we collected the Automatic Transient Evoked Otoacoustic Emissions test results (PASS or REFER). Audiological evaluation data collected were: acoustic immittance test results (type of tympanogram and Elicited or Non-Elicited Acoustic Reflex Measures), Distortion Product Otoacoustic Emissions test results (Elicited or Non-Elicited) and the Auditory Brainstem Response test (threshold value of the right and left V wave).


Steps to reproduce

Data of 63 children born to mothers who had contracted COVID19 during pregnancy were collected. All children born from 15 February 2020 to 15 February 2021 in the “Guglielmo da Saliceto” Piacenza Hospital were included. COVID19 mother infection was established with at least one positive nasopharyngeal swab and/or presence of specific immunoglobulin (IgM or IgG) for SARS-CoV-2 infection. Only children for whom both parents signed the Patient Informed Consent Form and whose mother signed her Patient Informed Consent Form prior to the first assessment were eligible for the clinical investigation. Children older than 6 months at the time of audiological evaluation were excluded from the study. In this dataset were collected personal data of children and mothers, newborn hearing screening and audiological evaluation results of the children. Children and mothers personal data were acquired by mother anamnesis. Automatic Transient Evoked Otoacoustic Emissions test was carried out using the Madsen AccuScreen device. Data of audiological evaluation were acquired via Tympstar-Pro device (for Acoustic immittance test), MADSEN Capella2 device (for Distortion Product Otoacoustic Emissions test) and Viking™ on Nicolet® EDX system (for Auditory Brainstem Response test). Data were collected in a Excel file. Children and mothers personal data, newborn hearing screening audiological data results were collected in different columns for each child (raw).


Azienda Unita Sanitaria Locale di Piacenza


Newborn Screening, Hearing Assessment