Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel

Published: 31 January 2024| Version 3 | DOI: 10.17632/mkt22rh344.3
Contributors:
Yanrong Ma, Fenling Ran,
,
,
, Xin-an Wu

Description

E1: Protein-binding ratio of uremic toxins; E2: Uptake of uremic toxins in OAT1-, OAT3- and MRP4-overexpressing cells; E3: Validation of potential biomarkers of OATs and MRP4 in vitro; E4: Validation of potential biomarkers of OATs and MRP4 in vivo; E5: Transweel; E6: Specificity evaluation of potential biomarkers; E7: Sensitivity-CMPF; E8: Sensitivity-Kynurenic acid; E9: Sensitivity-N-(cinnamoyl); E10: Correlation analysis in human; E11: Kinetics of cefmetazole and biomarker in rats； E13: Serum level of biomarker in human.

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Institutions

Lanzhou University

Categories

Pharmacology, Pharmacokinetics, Toxicity

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