Wood cookstove use is associated with gastric cancer in Central America, modified by the CYP1B1 genotype rs1800440, and independent of H. pylori cagA serostatus

Published: 13 June 2023| Version 1 | DOI: 10.17632/mrrjjp4j2w.1
Contributors:
, Dalton Norwood

Description

Wood cookstove use is associated with gastric cancer in Central America, modified by the CYP1B1 genotype rs1800440, and independent of H. pylori cagA serostatus. We conducted a population-based, case-control study (814 incident cases, 1,049 controls) in rural Honduras, a high-incidence region with a homogeneous diet and endemic H. pylori infection, primarily with the high-risk CagA genotype. We investigated factors including wood cookstove use, H. pylori CagA serostatus, and 15 variants from 7 metabolizing genes, and the interactions between wood stove use and the genetic variants.

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Institutions

University of Alabama at Birmingham

Categories

Genetics, Gastroenterology

Funding

National Cancer Institute

P01CA028842

National Cancer Institute

CA125588

Licence