An analysis of Gender Differences in American Indian and Alaskan Natives with Invasive Melanoma-Supplemental material

Published: 6 June 2022| Version 1 | DOI: 10.17632/mtfyy93k8j.1
Elizabeth Mata,


While gender strongly influences survival and presentation in melanoma, little is known about impact of gender in American Indians and Alaskan Natives (AI/AN). This study explored differences in tumor characteristics and survival between AI/AN males and females with invasive melanoma. Using the 2004-2018 National Cancer Database, a retrospective cohort study of AI/AN with primary invasive cutaneous melanoma was conducted. Statistical analysis included Mann-Whitney U (continuous variables), Chi-squared (categorical variables), Kaplan-Meier and log rank test (overall survival (OS)), and a multivariate Cox regression (independent survival predictors). Among AI/AN with invasive melanoma, women are diagnosed at an earlier age and stage, and they have better OS than men. Male gender is an independent predictor of worse OS. This dataset provides supplemental methods that were not able to be described in the research letter due to the limited word count. Additionally, we provide a figure that provides a detailed description of the case selection for this cohort of patients.



University of Arizona College of Medicine


Skin Cancer, Melanoma Skin Cancer, American Indian Health