Supplemental Fig 2. Dermatological manifestations in patients with vs. without VEXAS syndrome
Description
2A. Patients with VEXAS syndrome (a) Tender, red papules on the arm (patient #1). (b) Livedo racemosa on the leg, (c) inflammatory, edematous papules on the neck, and (d) acute lower limb ischemia (patient #2). (e) Firm, erythematous, purpuric, infiltrated plaques on the legs (patient #3). (f) Violaceous, flat plaques on the arm (patient #4). (g) Tender, red papules on the arm, (h) auricular chondritis, and (i) ulcerations of the palate (patient #5). (j) Violaceous papules on the legs, and (k) purpuric livedo on the arm (patient #6). (l) Inflammatory erythematous plaques and pustules (patient #7). 2B. Patients without VEXAS syndrome (a) Target-shaped erythematous plaques on the leg (patient #8). (b) Inflammatory edematous papules on the upper back (patient #9). (c) Purpuric plaques and pustules on the leg (patient #10). (d) Violaceous flat plaques on the arm (patient #11). (e) Inflammatory edematous papules and ulceronecrotic lesions on the hand (patient #12). (f) Pustules and ulceronecrotic lesions on the hand (patient #13). (g, h) Inflammatory pustules on the hand (patient #17). (i) Livedo racemosa on the leg, and (j) infiltrated erythematous plaque with large ulceronecrotic lesions on the thigh (patient #18). (k) Panniculitis on the thigh (patient #20). (l) Target-shaped infiltrated erythematous plaque on the knee, and (m) infected auricular chondritis (patient #21). (n, o) Tender, red papules on the trunk and hands (patient #22). VEXAS: vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome.