Antimalarial and Antipyretic Activities of Blighia sapida Stem Bark Fractions in Mice Infected with Plasmodium berghei
Description
These data sets were generated from a research that elucidates the antimalarial properties of different solvent fractions (n-hexane, dichloromethane, ethyl acetate, and n-butanol) extracted from the stem bark of Blighia sapida. The study hypothesizes that these fractions exhibit varying efficacies in suppressing parasitemia, prolonging survival, and alleviating symptoms like weight loss and temperature changes in Plasmodium berghei-infected mice. Additionally, the study posits that different classes of phytochemicals within these fractions contribute to their antimalarial activities. The dichloromethane fraction demonstrates the highest parasitemia suppression rate of 78.8% at an 800 mg/kg dose. The ethyl acetate fraction shows remarkable prophylactic efficacy, suppressing parasitemia by 89.4% at an 800 mg/kg dose while the ethyl acetate fractions at both 400 mg/kg and 800 mg/kg doses exhibit significant curative effects, including protection against weight loss and temperature changes. The study provides compelling evidence for the antimalarial efficacy of Blighia sapida stem bark fractions, particularly the ethyl acetate fraction. It lays the groundwork for future research aimed at isolating and characterizing active compounds, understanding their mechanisms of action, and optimizing dosages for therapeutic applications. The study's findings have significant implications for the development of novel antimalarial treatments, particularly those based on phytochemicals like alkaloids.