Data for: Synthesis of 1,4-diazabicyclo[2.2.2]octane and pyridinium based cationic polymers via ROMP and examination of their antibacterial activity and cytotoxicity
This paper focuses on the synthesis of cationic antibacterial polymers that could be a potential for new generation antibiotics with well-defined architecture derived by Ring Opening Metathesis Polymerization (ROMP) technique. Mono and double charge bearing quaternary groups have been used to synthesize cationic homopolymers (MWs: 3000 and 10000 g/mole) and their copolymers (MWs: 5000 g/mole). Hemolytic concentration (HC50, ≥1000 µg/mL) and MTS assay results showed that the polymers are non-toxic. It has been observed the double charge bearing polymers has the highest antimicrobial activity (S. aureus= 8 µg/mL) and a high selectivity with a value of 250 against S. aureus. Percent killing efficiencies were tested on glass surface and moderate killing efficiency was observed between a ranges 40-80% in 5 minutes. Cationic charge density and zeta potential studies were used to investigate mechanism of antimicrobial efficiency of the polymer in solution during the action against S. aureus to understand structure-activity relationship.