Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Moderbacher et al.
We conducted an analysis of SARS-CoV-2 specific adaptive immune responses during acute COVID-19 in comparison with convalescent COVID-19 and unexposed, healthy controls and identified that coordination between SARS-CoV-2-specific CD4 T cells and CD8 T cells limits disease severity in COVID-19. Aged individuals more often exhibited uncoordinated adaptive responses, potentially tied to scarcity of naive T cells, highlighting immunologic risk factors linked to COVID-19 disease severity. The data available here include all of the supplementary tables and figures, as well as a simplified parameters sheet with experimental and donor information for the healthy unexposed, acute COVID-19, and convalescent COVID-19 donor samples included in this study. Additional information about the supplementary materials, fields, field names, calculations, and patient cohorts are all provided in the published paper.