Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Moderbacher et al.

Published: 12-09-2020| Version 2 | DOI: 10.17632/n66n5pj4f6.2
Carolyn Rydyznski Moderbacher,
Sydney Ramirez,
Jennifer Dan,
Alba Grifoni,
Kathryn Hastie,
Daniela Weiskopf,
Simon Belanger,
Robert Abbott,
Christina Kim,
Jinyong Choi,
Yu Kato,
Eleanor Crotty,
Cheryl Kim,
Stephen Rawlings,
Jose Mateus,
Long Ping Victor Tse,
April Frazier,
Ralph Baric,
Bjoern Peters,
Jason Greenbaum,
Erica Ollmann Saphire,
Davey Smith,
Alessandro Sette,
Shane Crotty


We conducted an analysis of SARS-CoV-2 specific adaptive immune responses during acute COVID-19 in comparison with convalescent COVID-19 and unexposed, healthy controls and identified that coordination between SARS-CoV-2-specific CD4 T cells and CD8 T cells limits disease severity in COVID-19. Aged individuals more often exhibited uncoordinated adaptive responses, potentially tied to scarcity of naive T cells, highlighting immunologic risk factors linked to COVID-19 disease severity. The data available here include all of the supplementary tables and figures, as well as a simplified parameters sheet with experimental and donor information for the healthy unexposed, acute COVID-19, and convalescent COVID-19 donor samples included in this study. Additional information about the supplementary materials, fields, field names, calculations, and patient cohorts are all provided in the published paper.