Microbiome and Metabolome Profiles of High Screen Time in a Cohort of Healthy College Students

Published: 19 November 2021| Version 1 | DOI: 10.17632/nd64f8zchj.1
Contributors:
Paniz Jasbi,
Alex Mohr,
Qiyun Zhu,
Meg Bruening,
Haiwei Gu,
Corrie Whisner,
,

Description

As screens are increasingly integrated into every facet of modern life, there is growing concern over the potential effects of high screen time. Previous studies have largely utilized self-report data on mood and behavioral aspects of screen time. In this study, we explored the fecal microbiome and metabolome of a diverse group of 60 college students, classified by high (≥ 75 min/day) or low (0-75 min/day) self-reported screen time using 16S rRNA amplicon sequencing, targeted liquid chromatography-tandem mass spectrometry, and targeted short-chain fatty acid detection using gas chromatography-mass spectrometry. Several key taxa and metabolites were significantly altered between groups and found to be highly co-occurrent. Pathway and enzyme enrichment analyses indicated widespread dysfunction of amino acid metabolism. High screen time was also predicted to be associated with type I diabetes, obesity, chronic fatigue syndrome, and various manifestations of inflammatory bowel. These results provide a data-driven hypothesis for future experimental research.

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Institutions

Arizona State University

Categories

Metabolomics, Gut Microbiome

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