Supplemental Materials for "New Strategy for Liquid Nitrogen Treatment: Dual Cotton Swab Combined Cryotherapy"

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We have provided an instructional video. We propose an optimized approach that combines large (8 - 10 mm) and small (3 - 5 mm) cotton swabs for liquid nitrogen cryotherapy.

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We propose an optimized approach that combines large (8-10 mm) and small (3-5 mm) cotton swabs for liquid nitrogen cryotherapy . During the procedure, both swabs are dipped into liquid nitrogen simultaneously. The small swab then contacts the lesion . Through gravitational force, liquid nitrogen seeps along the cotton fibers or pre-designed channels to the small swab’s head. The large swab acts as a reservoir, transferring cryogen to the small swab via gravity. This ensures precise application of liquid nitrogen directly to the target lesion.

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