Data for: Jiadifenolide induces expression of cellular communication network factor (CCN) genes, and CCN2 possesses neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells

Published: 26 Sep 2019 | Version 1 | DOI: 10.17632/nmbmgmzv7z.1
Contributor(s):

Description of this data

Jiadifenolide induces expression of cellular communication network factor (CCN) genes, and CCN2 possesses neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells

Jiadifenolide has been reported to have neurotrophin-like activity in primary rat cortical neurons, and also possesses neurotrophic effects in neuronal precursor cells derived from human induced pluripotent stem cells (hiPSCs), as we have previously reported. However, the molecular mechanisms by which jiadifenolide exerts its neurotrophic effects in rat and human neurons are unknown. Thus, we aimed to investigate the molecular mechanisms and pathways by which jiadifenolide promotes neurotrophic effects. Here, we found that jiadifenolide activated cellular communication network factor (CCN) signaling pathways by up-regulating mRNA level expression of CCN genes in human neuronal cells. We also found that CCN2 (also known as connective tissue growth factor, CTGF) protein promotes neurotrophic effects through activation of the p44/42 mitogen-activated protein kinase (MAPK) signaling pathway. This is the first discovery which connects neurotrophic effects with CCN signaling.

Experiment data files

This data is associated with the following publication:

Jiadifenolide induces the expression of cellular communication network factor ( CCN ) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells

Published in: Biochemical and Biophysical Research Communications

Latest version

  • Version 1

    2019-09-26

    Published: 2019-09-26

    DOI: 10.17632/nmbmgmzv7z.1

    Cite this dataset

    Kuzuhara, Takashi (2019), “Data for: Jiadifenolide induces expression of cellular communication network factor (CCN) genes, and CCN2 possesses neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells”, Mendeley Data, v1 http://dx.doi.org/10.17632/nmbmgmzv7z.1

Statistics

Views: 436
Downloads: 210

Categories

Stem Cells Research, Induced Pluripotent Stem Cell, Cellular Mechanisms of Neurotrophic Factor, Induced Pluripotent Stem Cell Biology, Pluripotent Stem Cells

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?
You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report