Theta-Shaking Exercise Preserves Cognitive and Emotional Regulation in Aging Mice

Description

Research Hypothesis Theta-shaking exercise may enhance memory, neuronal health, and stress regulation in aging, particularly in memory-related regions like the hippocampus and lateral septum. Key Findings Memory (Y-Maze Test): Spontaneous alternation (working memory) improved significantly in the theta-shaking group at 20 and 30 weeks. Exploratory activity declined with age but was better preserved in the theta-shaking group. Anxiety (Marble Burying Test): Increased marble burying suggests heightened anxiety-related behavior in the theta-shaking group, intensifying over time. Histomorphology: Neuronal density increased in the subiculum, indicating neuroprotection. PGC1α-positive neurons were higher in the hippocampus, subiculum, and lateral septum, suggesting improved cellular health. Neurotrophic Factors (ELISA): BDNF levels showed a non-significant upward trend in the hippocampus. NT3 levels remained unchanged. Interpretation Theta-shaking enhances spatial memory and neuronal health, particularly through increased PGC1α expression and neuronal preservation. However, it may also elevate stress responses, and its effects on neurotrophic factors require further study. Conclusion Theta-shaking shows potential for memory enhancement and neuroprotection in aging but may also increase anxiety. Further research is needed to clarify mechanisms, especially regarding neurotrophic factors.

Categories

Funding

Licence