Published: 30 December 2016| Version 1 | DOI: 10.17632/nnkx572754.1
J Bertran-Gonzalez


\Data type and description: event-time stamp data. The time at which each event occurred (Y matrix, values 1-4) was stamped with a 10 ms resolution (Z matrix, centiseconds). Y matrix: 1=active response; 2=inactive response; 3=delivered pellet; 4=Magazine entry (time-controlled; consecutive entries within 200ms are not repeatedly stamped). Data were obtained through MED STATE NOTATION (MED Associates) and organized through MATLAB.


Steps to reproduce

\Experiment summary: 8 Aged (A1-8; 20-22 months old) and 8 Young (Y1-8; 2-3 months old) mice (C57BL6) were submitted to instrumental training (increasing random ratio schedule of reinfocement). CRF (days 1-3): constant reinforcement; RR5 (days 4-6): random ratio 5; RR10 (days 7-12): random ratio 10; RR20 (days 13-17): random ratio 20. Active lever counterbalanced (Left [L] or Right [R]). \Penalising regime: from day 10 of training, a penalizing protocol was introduced (pen5). From day 13, this regime was increased to pen7. Pen5: If the last 5 actions are not LP, probability of reward delivery is reseted; Pen7: If the last 7 actions are not LP, probability of reward delivery is reseted. \Test: on Day 18, exercise was the same as Day 17, pellets were not limited. After 20 minutes, behaving mice were rapidly anaesthetised and intracardiacally perfused (see methods)


The University of Queensland Queensland Brain Institute


Operant Conditioning, Sequence Learning