Published: 8 February 2021| Version 1 | DOI: 10.17632/pc773fty8m.1
Poh Ying Lim


time to early TB treatment interruption among newly diagnosed TB patients


Steps to reproduce

This prospective multi-centric longitudinal study aimed to determine the prognostic factors for time to intensive phase treatment interruption among new pulmonary Tuberculosis (TB) smear positive patients. Multivariate Cox proportional hazard regression analyses were performed to analyse the prognostic factors of treatment interruption. Of 439 participants, 104(23.7%) developed treatment interruption and with 67.3% of treatment interruption occurring in the first month of treatment. Median survival time was 56.00 days (95%CI=55.00-56.00), with overall survival probability of 73.9%. Being a current smoker and having a history of hospitalization, internalized stigma, low TB symptoms score, and waiting time spent at Directly Observed Treatment, Short-course(DOTS) centre were prognostic factors of treatment interruption.