Effect of Ginkgo Biloba Extract on TGF-β1-induced Myocardial Fibroblast Fibrosis in Neonatal Rats

Published: 17 April 2023| Version 2 | DOI: 10.17632/pdvvpvwytg.2
yingzhu Jin, luo zhenhua, Fangfang Hu, Hong Li, Shun Wang, ZongGang Duan, XinLin Xiong, Wei Li


This dataset contains immunohistochemical detection and analysis of the MMPs system (including significant reduction in the secretion and deposition of collagen I and III, significant reduction in the expression levels of MMP-2 and MMP-9, and significant inhibition of TIMP-1 expression) in cardiac fibroblasts


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This investigation revealed that TGF-β1 can promote the proliferation of CFb, which can be strongly inhibited by GBE, the considerable reduction in the expression of TGF-β1, and type I and III collagen secretion and deposition, the MMP-2 and MMP-9 expressions, which hindered the expression of TIMP-1.


Guizhou Medical University


Myocardial Function, MTT Assay


Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320003)

Science and Technology Research Project of Guizhou Administration of Traditional Chinese Medicine QZYY2017-026

The Science and Technology Department of Guizhou Province Platform for talents (2018)5608

The Science and Technology Department of Guizhou Province(2019)2800

the Education Department of Guizhou Province KY(2016)070