Effect of Ginkgo Biloba Extract on TGF-β1-induced Myocardial Fibroblast Fibrosis in Neonatal Rats

Published: 17 April 2023| Version 2 | DOI: 10.17632/pdvvpvwytg.2
Contributors:
yingzhu Jin, luo zhenhua, Fangfang Hu, Hong Li, Shun Wang, ZongGang Duan, XinLin Xiong, Wei Li

Description

This dataset contains immunohistochemical detection and analysis of the MMPs system (including significant reduction in the secretion and deposition of collagen I and III, significant reduction in the expression levels of MMP-2 and MMP-9, and significant inhibition of TIMP-1 expression) in cardiac fibroblasts

Files

Steps to reproduce

This investigation revealed that TGF-β1 can promote the proliferation of CFb, which can be strongly inhibited by GBE, the considerable reduction in the expression of TGF-β1, and type I and III collagen secretion and deposition, the MMP-2 and MMP-9 expressions, which hindered the expression of TIMP-1.

Institutions

  • Guizhou Medical University

Categories

Myocardial Function, MTT Assay

Funders

  • Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320003)
  • Science and Technology Research Project of Guizhou Administration of Traditional Chinese Medicine QZYY2017-026
  • The Science and Technology Department of Guizhou Province Platform for talents (2018)5608
  • The Science and Technology Department of Guizhou Province（2019）2800
  • the Education Department of Guizhou Province KY(2016)070

Licence