Respiratory Pressure and Flow Data Collection Device Providing a Framework for Closed-Loop Mechanical Ventilation

Published: 14 October 2024| Version 2 | DOI: 10.17632/pf5dbgwkbm.2
Contributors:
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Description

This repo contains the files to replicate a pressure and flow sensor device offering personalized mechanical ventilator support in a closed-loop control system. This device improves on previous respiratory data collection devices and is optimized for the invasive mechanical ventilation use case. In current practice, patient response to mechanical ventilation is highly variable, and not patient specific. Furthermore, current weaning best-practice relies on clinical experience which can lead to variability and inequity in both care and health outcomes. Personalized care can improve these inequities when combined with digital twin models, which simulate physiology based on patient specific data. The device consists of two 3D printed custom Venturis and a Y-piece, with differential pressure sensors measuring gauge, inhalation and exhalation pressure at the patient. The system uses BLE communication between ESP32-S3 development boards to facilitate the closed loop framework. Within this loop, pressure data is sent to a digital beside sheet, which runs digital twin protocols and sends commands to a BLE controlled ventilator. Overall, this device allows the future development and validation of personalized mechanical ventilation treatment through integration with digital twin models.

Files

Steps to reproduce

1. Place an order for all components listed on the bill of materials. 2. Populate the PCBs in accordance with the Altium project files. To populate the PCBs solder on the 100 nF Capacitor, 2k7 Resistors, 4k7 Resistors, headers, and sensors. Solder Socket Headers into the through holes for the ESP32, before mounting it. 3. Wire the Switch and 3PinMOLEXKKConn. If a switch with LED is not available, a basic switch, LED, _resistor, and 3 pin MOLEX connector. 4. Print the Housing Top and Housing Base on the same print plate orientated. The parts were printed in PLA on a BambuLab Printer with automatic tree support and an extra fine layer height of 0.08 mm. All other 3D printed parts should be printed on a separate plate, with normal support and a layer height of 0.12 mm. 5. Remove support material from components and attach barbs to Venturis and Y-piece using superglue. Remove the IPN913948 Membrane from Hudson RCI One-Way Valve and attach to 3D printed One Way Valve. Insert into Y-piece and Inhalation Venturi with membrane facing out. Tap the four small holes on each of Housing Top and Housing Base with a M3 x 0.5 mm tap. 6. Connect inhalation and exhalation Venturis. When placed on a flat surface, the inhalation barbs should be parallel to the surface. The exhalation barbs should be at a 45 degree angle down from the inhalation barbs and the Y-piece barb should face directly into the surface. 7. Connect the inhale and exhale Sensor Boards to the Control Board using 3-pin connectors. Connect the Gauge Board to the Control Board using the 4-pin connector. 8. Attach a short length of Silicone Tubing to the sensor ports. The lengths are dependent on the positioning of each sensor and should be adjusted to suit. Each sensor has two ports, one that sits higher than the other. The higher port on each Sensor Board sensor should be connected to the inlet barb of their respective Venturi. The higher port of the Gauge Board sensor should be connected to the Y-piece barb. The lower port of each Sensor Board sensor should connect to the throat barb of their respective Venturi. The lower port on the Gauge Board sensor should be left disconnected. 9. Attach the Gauge Board to the Base Plate using M2 screws. Attach Control Board to the Base Plate with M3 screws. Leave the inhale and exhale Sensor Boards loose but arrange them. Do not attach the switch circuit at this stage. 10. Slide Base Plate into Housing Base and connect the switch circuit. Align Inhalation Venturi, Exhalation Venturi and Y-Piece above the system and connect the end of the silicone tube to the free barbs. 11. Attach Housing Top to Housing Base and insert 4 M3 grub screws into the tapped holes to secure the external housing shut. Refer to the README.md file for operation instructions.

Institutions

University of Canterbury

Categories

Engineering, Biomedical Device, Respiratory Airway, Mechanical Ventilation

Licence