Embryo morphokinetics is potentially associated with clinical outcomes of single embryo transfers in preimplantation genetic testing for aneuploidy cycles
Description
Time-lapse microscopy was used to compare morphokinetic variables between expanded blastocysts derived from preimplantation genetic testing for aneuploidy cycles using high-resolution next-generation sequencing (hr-NGS). The clinical efficacy of the morphokinetic algorithm KIDScoreTM D5 was evaluated after euploid SETs.
Files
Steps to reproduce
Data derived from biopsied blastocysts cultured in a TL incubator (Embryoscope+) between Jan 2017 and Aug 2018 in Lee Women’s Hospital were retrospectively assessed. Clinical outcomes from 107 euploid blastocyst SETs were included in this study. All embryos were obtained after fertilization of autologous or donated oocytes through intracytoplasmic sperm injection or conventional IVF. The exclusion criteria were low anti-Mullerian hormone level (≤ 1.1 ng/mL), advanced maternal age (autologous patients or oocyte donors with age ≥ 38 years), severe endometriosis, severe uterine pathology (adenomyosis and congenital or acquired uterine abnormalities), and surgical sperm retrieval. Additionally, patients who experienced at least three previous failures of euploid embryo transfers were excluded.