Ischemia-induced LRRK2 impairs endothelial and neuronal BDNF signalling and is reversed by salidroside

Name: Ischemia-induced LRRK2 impairs endothelial and neuronal BDNF signalling and is reversed by salidroside
Creator: Xuerui Zheng
Published: 2026-02-04T20:36:52.215Z
Keywords: Cerebral Ischemia

Zheng, Xuerui; Chen, Jingquan; Li, Huangqi; Lan, Ruanyangyang; Shi, Xin; Wu, Qingqing; Wu, Huiling; Hong, Haimian; Wenfang, Lai; Brown, John; Hong, Guihu

doi:10.17632/pr9gj9tkcd.1

Ischemia-induced LRRK2 impairs endothelial and neuronal BDNF signalling and is reversed by salidroside

Published: 4 February 2026| Version 1 | DOI: 10.17632/pr9gj9tkcd.1

Contributors:

Xuerui Zheng, Jingquan Chen, Huangqi Li, Ruanyangyang Lan, Xin Shi, Qingqing Wu, Huiling Wu, Haimian Hong, Lai Wenfang, John Brown, Guihu Hong

Description

Overactive mutations of leucine-rich repeat kinase 2 (LRRK2) are neurotoxic, cause Parkinson’s disease, associate with increased risk of ischemic stroke, and their pathological effects can be modified by BDNF mutations. Salidroside is a bioactive compound derived from Rhodiola species, which are traditionally used for stroke treatment. Here we investigated whether LRRK2 modulates BDNF signalling and whether this might explain how salidroside salvages ischemic damage.

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National Natural Science Foundation of China
Beijing, Beijing
Grant ID: 82174001
Fujian Provincial Department of Science and Technology
Fujian, Fuzhou
Grant ID: 2024J01776

Ischemia-induced LRRK2 impairs endothelial and neuronal BDNF signalling and is reversed by salidroside

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