Asymmetric distribution of centromeric components in midgut stem cells and their role in cell types with varying differentiating potential

Published: 9 February 2018| Version 1 | DOI: 10.17632/py9x5h9gvn.1
Ana Garcia del Arco,
Bruce A. Edgar,
Sylvia Erhardt


CENP-A is a histone variant critical for centromere function during mitosis. We have analyzed CENP-A in stem cells of the fly intestine and found an symmetric inheritance of pre-existing and newly synthesized CENP-A. CENP-A and its loading factor CAL1 are essential in differentiated cells, suggesting non-mitotic roles