Hesperidin supplementation to alternate day fasted rats exhibit synergistic effects in providing protection against aging-induced oxidative damage and elevated levels of inflammatory cytokines
Description
This data contain experimental values of some biochemical experiments conducted on rats supplemented with hesperidin (antioxidant) and also maintained on alternate day fasting (an intermittent fasting regimen). It compares the differences and additional changes obtained on administration of hesperidin to rats maintained underalternate day fasting. Alternate day fasting (ADF), a dietary restriction regimen is beneficial in delaying aging and associated morbidities by reducing oxidative stress and inflammation. Hesperidin is a flavonoid antioxidant known for its anti-oxidant and anti-inflammatory property. In this study, we aimed to evaluate the synergistic role, if any, of hesperidin supplementation and ADF regimen in Wistar rats on biomarkers of aging and inflammation. Materials and methods. Male Wistar rats (8-10 months) were divided into four groups: Group I. Control; Group II. Alternate day fasting (ADF); Group III. Hesperidin; Group IV. ADF+ Hes (maintained under ADF regimen and given hesperidin regularly). We estimated some crucial biomarkers of oxidative stress and antioxidant defense like FRAP, GSH, PMRS, MDA, PCO, AOPP, NO, insulin, adiponectin and inflammatory cytokines (TNF-α. IL-6, CRP and COX). Our results show evidence of a synergistic benefit obtained in few parameters of antioxidant defense and inflammation. The results support the administration of hesperidin during ADF regimen to obtain additional benefits and protection from aging induced oxidative stress and to reduce the incidence of common metabolic morbidities like impaired glucose levels and altered biochemical parameters.