Inhibition of DHODH Activates Pyroptosis and cGAS-STING Pathways to Enhance NK cell Infiltration Mediated Anti-tumor Immunity in Melanoma

Published: 19 February 2024| Version 1 | DOI: 10.17632/r8c8nrphsh.1
Contributor:
Ruizhuo Lin

Description

Our research indicated that inhibition of DHODH activates pyroptosis and cGAS-STING pathways to enhance NK cell infiltration. And the tumor-infiltrating NK cells facilitate melanoma cells pyroptosis which providing a positive feedback mechanism for DHODH-mediated anti-tumor immunity. These date are the original date of our research and the key resources are also showed in this date.

Files

Categories

Cancer Immunotherapy

Licence