Modulation of microbiota metabolism in cardiac surgical patients: a single-center prospective randomized interventional clinical trial
Description
A randomized prospective interventional study was conducted, which included 58 patients who underwent planned surgical intervention on the heart and main vessels under artificial circulation. The patients were divided into two groups: I - main group, patients who underwent modulation of microbial metabolism using antibiotics-inhibitors of protein synthesis (n=30), II - control group, patients without modulation of microbial metabolism (n=28). Blood serum samples from patients were taken before surgery, on the 3rd and 6th days of the postoperative period, in which, along with clinical blood parameters and biomarkers of inflammatory response, concentrations of clinically significant aromatic acids (phenyllactic (PhLA), 4-hydroxyphenylacetic (p-HPhAA), 4-hydroxyphenyllactic acids (p-HPhLA) and their amount (∑AMM)), in μmol/L were determined.