Underlying data for 'Risk Factors and Mortality Outcomes of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Bacteremia: A Retrospective Cohort Study from Two Indonesian Referral Hospitals'
Description
This is database of retrospective cohort study to evaluate for the Risk Factors and Mortality Outcomes of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Bacteremia patients. The sample was conducted using the medical records of all inpatients from January to December 2019 at two referral hospitals in Jakarta, Indonesia, namely Cipto Mangunkusumo National Hospital and Persahabatan Central General Hospital. This study is approved by the Ethics Commission of The National Institute of Health Research and Development (LB.02.01/2/KE.184/2018), the Health Research Ethics Committee of the Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital (KET-169/UN2.F1/ETIK/PPM.00.02/2022), and the Health Research Ethics Committee of Persahabatan Central General Hospital (42/KEPK-RSUPP/07/2018). The target population was patients with positive E. coli blood cultures which were taken once during hospitalization in all age groups. Patients who were treated for less than 48 hours, had negative E. coli blood cultures or with incomplete medical record data were excluded. Positive E. coli blood cultures were phenotypically differentiated into ESBL- and non-ESBL-producing colonies using the VITEK®2 compact system algorithm (bioMérieux, France). Patient characteristics, length of stay, source of infection, comorbidity, and several risk factor variables for ESBL-producing E. coli infection including age, history of antibiotic therapy, utilization of medical devices, Charlson Comorbidity Index (CCI), and history of hospitalization.
Files
Steps to reproduce
Statistical analyses were conducted with SPSS version 20 by IBM Corp. The basic and clinical characteristics of the research subjects were presented in tables. Categorical data were presented in proportion. The data were presented in mean and standard deviation if they were normally distributed and median and minimum-and-maximum values if not. Risk factors for acquiring ESBL-producing E. coli bacteremia and risk factors for mortality in patients with such condition were analyzed. Bivariate analysis using Chi-square or Fisher’s exact test was performed to examine the significance of the odds ratio (OR). Multivariate logistic regression test was subsequently performed to identify significantly contributing factors for variables with a bivariate analysis p value of less than 0.25.