DARTS Prospective Oddball MDD
Description
Participants were recruited from the Tallahassee, Florida, USA community via advertisements, flyers, and other outlets from 2013 to 2016 to participate in a large longitudinal randomized clinical trial (RCT) project targeting risk factors for anxiety and mood disorders (clinical trial #: NCT01941862). Interested participants completed a phone screen to determine eligibility, attended a baseline visit during which verbal and written explanations of the procedures of the study were provided before written informed consent was obtained, and completed self-report questionnaires as well as a clinical interview. The sample consisted of adults between the ages of 18 and 79 who had normal or corrected-to-normal vision and no lifetime history of significant head trauma or neurological diseases. Further exclusion criteria included the presence of a lifetime diagnosis of a manic/hypomanic episode (i.e., bipolar disorders) or psychotic disorders. Participants were included in the current study if they met diagnostic criteria for any current depressive disorder at the baseline assessment, which was confirmed via structured clinical interviewing (i.e., major depressive disorder [MDD], persistent depressive disorder [PDD], or depression not other specified) and were randomized to either the mood reduction intervention, combined mood and anxiety reduction intervention, or the repeated contact control condition. The study was conducted in accordance with the ethical guidelines of the Declaration of Helsinki and was approved by the Florida State University Institutional Review Board. The current dataset initially comprised a total of 95 participants experiencing depression at the baseline assessment (38 randomized to mood reduction intervention, 31 randomized to the combined intervention, and 26 randomized to the repeated contact control condition); however, 54 participants returned for the six-month follow-up and an additional six participants were excluded due to poor EEG signals after visual inspection. Therefore, the final sample consisted of 48 total participants. The present dataset consists of the following variables: baseline neural activity (i.e., P300 amplitude) collected during an affective visual oddball (target, distractor, and standard), demographic information (age, gender, race), intervention group, baseline depression severity (BDI), six-month follow-up depression severity (BDI), and six-month follow up depression diagnoses status (SCID).
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Funding
American Foundation for Suicide Prevention
DIG-0-030-12