Data for: Differential inflammatory potential of particulate matter (PM) size fractions from Imperial Valley, CA

Published: 14 October 2020| Version 2 | DOI: 10.17632/s29sjdh7xv.2
Contributor:
Savannah Mack

Description

Ultrafine, fine, and coarse PM samples were collected and extracted separately. Analyses of the chemical compositions for each size fraction were performed, and biological response was measured by exposing a cell line of macrophages to particles and quantifying subsequent gene expression. Biological measurements demonstrated coarse PM induced an inflammatory response in macrophages measured in increases of inflammatory markers IL-1ß, IL-6, IL-8 and CXCL2 expression, whereas ultrafine and fine PM only demonstrated significant increases in expression of CYP1a1. These differential responses were due not only to particle size, but to the distinct chemical profiles of each size faction as well.

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