Bioequivalence Study of Locally Manufactured Cetirizine Tablets in Ghana

Published: 1 July 2021| Version 1 | DOI: 10.17632/s4wfx5xrk3.1


The datasets were reverse-phase High-Performance Liquid Chromatographic concentrations of unchanged reference and test cetirizine excreted in the urine of twelve healthy male volunteers after taking 10 mg of cetirizine tablet. The data collection aimed to study the bioequivalence of locally manufactured cetirizine tablets with the innovator counterpart. We designed the study under the (WHO, 2006) guideline for bioequivalence study in a two-way-crossover design, fed and fasted mode. Samplings include blank urine samples before the drug intake, followed by subsequent samples throughout the 24-hour study duration. The values are mean concentrations of triplicate readings together with the standard deviations. Further interpretations of the datasets can provide more insight into the pharmacokinetics study of locally manufactured cetirizine tablets. It can also serve as a model to design computational simulations for pharmacokinetics studies.



Kwame Nkrumah University of Science and Technology College of Health Sciences


Pharmacokinetics, Bioanalytical Chromatography, Bioequivalence, Urinary Analysis