Genetic variants and haplotypes in the renin-angiotensin system could affect bleeding complications among Korean mechanical heart valve patients on warfarin

Published: 22 January 2021| Version 1 | DOI: 10.17632/s5cngbxmy7.1
Joo Hee Kim,
Jeong Yee,
Byung Chul Chang,
Jee Eun Chung,
Kyung Eun Lee,
Hye Sun Gwak


This study aimed to investigate the effects of genetic variants and haplotypes in the renin–angiotensin system (RAS) on warfarin-induced bleeding complications at therapeutic international normalized ratios (INRs) among Korean patients with mechanical heart valve replacements.