Biosafety assessment of engineered CCL20 locked dimers in vivo
Published: 21 November 2025| Version 1 | DOI: 10.17632/s6jwhkxn8c.1
Contributors:
, Description
Single cell RNA sequencing data of 4 spleens from 6-week old male C57/BL6 mice treated with vehicle PBS and 4 spleens from mice treated with 200ug CCL20LD every other day by intraperitoneal injection for 21 days. Barcodes, features, and matrix files provided for each sample, as well as a final .RDS Seurat object of all integrated samples annotated ("subclustered_b_cells.RDS"). More info can be found in the associated paper. The code for the analysis can be found at https://github.com/The-Michael-Dwinell-Lab-at-MCW/CCL20LD-Safety-and-Efficacy/tree/main
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Institutions
- Medical College of WisconsinWI, Milwaukee
Categories
Chemokine Receptor, Chemokine, Single-Cell RNA Sequencing