Meta-Analysis dataset: Methionine Sources for Weaned pigs

Published: 25 May 2023| Version 2 | DOI: 10.17632/s7v6nnj852.2
Aline Remus


The datasets generated in the trials and by simulation during the current study belong to His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food Canada. Data use is subject to obtaining permission of the representative of His Majesty the King in Right of Canada. Please contact the author for further information. Data collection (search strategy and inclusion criteria) A systematic review was conducted using the PRISMA statement (Page et al., 2021) to update the dataset previously used in a meta-analysis (Remus et al., 2015). The platforms Pubmed (126 references), ProQuest (235 references), Scopus (143 references) and Science Direct (1,663 references) were searched to identify studies reporting experimental dose-response results for the different Met sources used in pigs from weaning to finishing. The review question was proposed using the “PICo” framework, where a set of keywords was created, including elements designating population (pigs, piglets), interest (Met requirements, Met supplementation), and context (growth performance). After 293 duplicate references were removed, 1,898 studies remained. These studies were analyzed according to the following selection criteria: 1) research must have been conducted on pigs; 2) the paper must have been published between 1990 and 2021; 3) and it must present growth performance data. Based on these criteria, 1,779 papers were eliminated after the titles were assessed, while another 74 were eliminated after reading the abstract. An additional search in Google Scholar was performed. The keywords used were “pigs,” “Met,” and “growth,” and 24 adittional papers were selected according to the three previously stated criteria. At this step, the database comprised 45 references that were individually screened for full-text analysis. The inclusion criteria were as follows: 1) Studies must present treatments with different sources of free Met such as L-Met, DL-Met and/or OH-Met; 2) Free Met must have been provided at one or more inclusion levels; 3) Met must be the first limiting amino acid according to the material and methods; 4) Papers must present the nutritional composition of the experimental diets. A total of 33 studies were retained for the meta-analysis at the end of the evaluation process. Due to the small number of studies on the growing and finishing phase, only the post-weaning phase (5-25 kg body weight) was included in the analysis. Post-weaning data were present in 24 papers used in the meta-regression and meta-analysis. The ingredient composition of each diet was computed in spreadsheets and used to estimate (recalculate) the dietary composition in terms of net energy, SID AA, as well as mineral composition using the software EvaPig®. When available, the analyzed total AA composition provided by the authors was used to estimate SID values with EvaPig®. The codes used in the database are described on the Legend sheet.



Agriculture and Agri-Food Canada


Nutrition, Amino Acids, Pig, Meta-Analysis