Data for: Higher and Increased Concentration of hs-CRP within Normal Range Can Predict the Incidence of Metabolic Syndrome in Healthy Men
Subjects Baseline and follow-up data were collected through comprehensive health examination from January 2002 to December 2009 at one comprehensive examination center of the hospital. Study subjects were male workers in semiconductor and electric appliance manufacturing company. They took follow-up examinations every year or every other year. Study subjects were limited to those who had no metabolic abnormalities in 2002 out of 15,347 male workers who received health examinations in 2002. Subjects who had any one of five components of metabolic syndrome (total 10,251, metabolic syndrome: 2,182) were excluded. hs-CRP and HOMA-IR are indicators reflecting inflammatory response and insulin resistance, respectively. Both of them are known as main mechanisms involved in the development of metabolic syndrome. Thus, those who had blood hs-CRP concentration over 1.0 mg/L (n = 4,132) and those who had homeostasis model assessment-insulin resistance (HOMA-IR) over 2.5 (n = 2,181)  were also excluded. Based on self-reported questionnaire, subjects who reported a history of high blood pressure (n = 106), diabetes (n = 33), dyslipidemia (n = 125), cardiac disorder (n = 5), thyroid disease (n = 10), cancer (n = 27), asthma (n = 5), and immune disease (n = 2), or taking antibiotics, tetracycline, and steroidal drugs (n = 48) were also excluded. Subjects with missing crucial variables such as hs-CRP and HOMA-IR (n = 825) were also excluded. Hence, 3,748 subjects were designated as the study population for 2002. Out of these subjects, final analysis was conducted on 3,386 subjects after excluding 362 who were unable to be followed up before December 31, 2009 (Fig. 1). The study protocol was reviewed and approved by the Institutional Review Board of Kangbuk Samsung Hospital (KBC12052) where permitted an exemption for informed consent in this study.