Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations

Published: 12 May 2020| Version 1 | DOI: 10.17632/sc5tfwt4nr.1
Tamara Maes,
Cristina Mascaró,
David Rotllant,
Michele Matteo Pio Lufino,
Angels Estiarte,
Nathalie Guibourt,
Fernando Cavalcanti,
Christian Griñán-Ferré,
Mercè Pallàs Lliberia,
Roser Nadal,
Antonio Armario,
Isidro Ferrer,
Nuria Valls,
Matthew Fyfe,
Marc Martinell,
Julio César Castro Palomino,
Carlos BUESA


Data corresponding to Fig 1 to Fig 11 Data corresponding to S1 Fig to S6 Fig Data corresponding to S Fig Reply to reviewers


Steps to reproduce

The original data files have been edited to blind or remove data from other compounds analyzed in parallel to ORY-2001 or other information not object of the manuscript, and to remove personal information. Discovery or blinding codes were substituted for ORY-2001, ORY-LSD1 or compound names used in the manuscript by Maes et al. (doi 10.1371/journal.pone.0233468). Detailed methods use to produce this dataset are available in S2 File: Supporting Materials and Methods.


Epigenetic Therapy