Data for: Anti-diabetic potential of Momordica charantia foliage extract with anti-inflammatory and antioxidant effects

Published: 11-04-2020| Version 1 | DOI: 10.17632/sgrhp2jdgx.1
Contributor:
Alicia Lagarto

Description

The data show the processed data for the evaluation of anti-hyperglycemic, antioxidant and anti-inflammatory effects of Momordica charantia foliage extract in addition to safety evaluation through acute toxicity and genotoxicity assays. The anti-hyperglycemic effect of the extract was determined in normal rats and diabetic mice. Antioxidant activity was then characterized using ABTS, peroxyl and superoxide radical scavenging capacity tests. Anti-inflammatory effects were assayed on cotton pellet granuloma in mice and carrageenan-induced pleurisy in rats. The toxicological evaluation was carried out by acute toxicity and genotoxicity assays. Treatment with M. charantia extract resulted in a significant reduction in blood glucose in normal rats and diabetic mice improving the lipid profile and in vivo radical scavening capacity of diabetic mice. The extract showed a potent in vitro radical scavenging capacity with IC50 values between 12 and 60 µg/mL and produced anti-inflammatory effects in both cotton pellet granuloma in mice and carrageenan induced pleurisy in rats. Acute toxicity test did not reveal any significant change. Genotoxicity evaluation indicated that the extract was not genotoxic but at high dose, induced cytotoxic activity in bone marrow erythrocytes.

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