Supplementary information of Novel therapeutic strategy for intractable keloids: Suppression of intracellular mechanotransduction and actin polymerization via Rho-kinase pathway inhibition
Description
Supplementary materials and supplementary figure legends. Supplementary figure S1. Expression of ROCK1 in keloid tissues and fibroblasts. Supplementary figure S2. Mechanical stress induces ROCK1 expression and F-actin rearrangement in keloid fibroblasts. Supplementary figure S3. Suppressed ROCK1 induces F-actin rearrangement in KFs through Rho/ROCK1 transduction pathway. Supplementary figure S4. Effect of Y27632 on cytoskeletal rearrangement of F-actin in KFs. Supplementary figure S5. Inhibition of ROCK1 attenuates skin fibrosis and cell migration in KFs. Supplementary figure S6. Cyclic stretch-activated ROCK1 triggers nuclear translocation of YAP and MRTF. Supplementary figure S7. Histological and immunohistochemical images of nodules formed by human KFs in SCID mice 7 days post-Y27632 treatment. Supplementary figure S8. Histological images of nodules formed by human KFs in SCID mice 7 days post-Y27632 treatment. Supplementary figure S9. Immunohistochemical images of the nodules formed by human KFs in SCID mice 7 days post Y27632 treatment.
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Institutions
- Seoul National University
- Seoul National University Seoul Metropolitan Government Boramae Medical Center