Intracerebral Electric Field Magnitudes during tACS in Human In-Vivo

Published: 09-07-2021| Version 1 | DOI: 10.17632/sk279ktjv3.1
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Description

This dataset is used in our study entitled : "In-vivo Evidence of Substantial Electric Fields in Human Deep Cortical Structures During Transcranial Electrical Stimulation". Our main purpose was to measure the electric field in several deep brain structures during TES in humans in-vivo. In addition, we investigated the effects of TES intensities and montages on the intracerebral EF. Simultaneous bipolar transcranial alternating current stimulation and intracerebral recordings (SEEG) were performed in 7 drug-resistant epileptic patients. TES was applied using small high-definition (HD) electrodes. Patients gave their informed consent prior to participation (NCT03644732). Two low intensities were applied to 6 patients (0.5 and 1mA) and 15 different montages were tested on 1 patient. At 1mA intensity, we found an EF magnitude up to 0.49, 0.38 and 0.09 V.m-1 in the amygdala, the hippocampus, and the cingulate gyrus, respectively. An average of 0.15 ± 0.08 V.m-1 was measured in all deep brain areas. The EF was strongly correlated with the TES intensities (R= [0.98-1]). The TES montages that yielded the maximum EF in the amydgalae were T7-T8 and in the cingulate gyri were C3-FT10 and T7-C4. A substantial EF in deep brain structures is achievable using low intensities and small HD electrodes. EF magnitude is highly correlated to the stimulation intensity and dependant upon the stimulation montage. This dataset contains 7 individual anonymized MRI (nifti format) and 26 files (xls format) with intracerebral electrical field (EF) magnitudes (in V/m) and 3D SEEG contact coordinates (in SCS space). This dataset should serve to compare these empirical human in-vivo EF magnitudes with estimated EF magnitudes from computational models of current flow.

Files

Steps to reproduce

- Patient inclusion - SEEG investigation - MR and postoperative CT acquisition and co-registration (3D SEEG electrodes localizations) - Simultaneous tACS and SEEG recording - Electric field magnitudes calculation