Clinical Characteristics of Severe COVID-19 in Italy

Published: 26 March 2021| Version 1 | DOI: 10.17632/sn35f9x3vt.1
Matteo Briguglio


Italy was one of the worst affected European countries during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. More than 50% of Italian cases occurred in the northern region of Lombardy, where the saturation of health services between March and April 2020 forced hospitals to allocate patients according to available resources. Eighteen severe coronavirus disease 2019 (COVID-19) patients were admitted to our hospital needing intensive support. Given the disease fatality, we investigated the patients' characteristics to identify mortality predictors. We counted seven deaths from multiple organ failure, two from septic shock, and two from collapsed lungs. The maximum case fatality was observed in patients who contracted SARS-CoV-2 in hospitals. The fatal outcome was associated with the following baseline characteristics: polymorbidity (OR 2.519, p = 0.048), low body mass index (OR 2.288, p = 0.031), low hemoglobin (OR 3.012, p = 0.046), and antithrombin III (OR 1.172, p = 0.048), along with a worsening of PaO2/FiO2 ratio in the first 72 h after admission (OR 1.067, p = 0.031). The occurrence of co-infections during hospitalization was associated with a longer need for intensive care (B = 4.511, p = 0.001). The dataset was used to write the article "Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic", which was published by the Journal Frontiers in Medicine in 2021 (DOI:10.3389/fmed.2021.582896).



IRCCS Istituto Ortopedico Galeazzi


Infectious Disease, Sepsis, Anesthesia, Intensive Care, Intubation, Systemic Inflammatory Response Syndrome, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19