Monitoring Diffuse Injury in the EAE model for MS using CEST MRI

Published: 31 July 2019| Version 1 | DOI: 10.17632/sr567vff6p.1
Aline Thomas


Comparison of MRI methods to predict and monitor disease progression in a multiple sclerosis mouse model. T1w/FLASH, T2w, T2*w, and metabolite-sensitive chemical exchange saturation transfer (CEST) MRI values (.xls) were acquired in the chronic experimental autoimmune encephalomyelitis (EAE) model (C57Bl/6, female, 6-10 weeks old, active induction against myelin antigen MOG35-55) at multiple regions of the brain and spinal cord (.ppt) over the course of the disease as paralysis progressed. CEST methods include the continuous wave (CW, at the 0-4 ppm frequencies), amide proton transfer (APT, at 3.6 ppm), and on resonance variable delay multiple pulse (onVDMP, at 0 ppm).


Steps to reproduce

Re-create ROIs using image processing software FIJI/ImageJ, which can then be converted to Matlab.


Central Nervous System, Image Segmentation, Multiple Sclerosis