Supplemental Appendix for: Reproducibility of Histopathologic Diagnosis of Melanoma and Related Melanocytic Lesions: Results from a Testing Study and a Reference Guide for Providers

Published: 16 June 2022| Version 1 | DOI: 10.17632/ssrfvm5pgg.1
Contributor:
Megan Eguchi

Description

Supplemental Appendix for: Reproducibility of Histopathologic Diagnosis of Melanoma and Related Melanocytic Lesions: Results from a Testing Study and a Reference Guide for Providers Our objective was to quantify intraobserver reproducibility among the most common diagnoses encountered in routine clinical practice. For providers who utilize dermatopathology services, our findings can serve as a reference guide to counsel patients on the limits of histopathology in the diagnosis of melanocytic lesions. We found that diagnoses from moderately dysplastic nevus to melanoma in situ were not reproducible (intra-observer reproducibility <50%), reproducibility of pT1a invasive melanoma was modestly better, and most reproducible were the extremes of nevus/mild dysplasia and invasive melanoma (≥ pT1b). This document provides study background information and supplemental tables and figures to accompany a research letter submitted to the Journal of the American Academy of Dermatology International.

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Institutions

Institut Curie, University of Pennsylvania Department of Pathology and Laboratory Medicine, University of Washington School of Medicine, University of California Los Angeles David Geffen School of Medicine, University of Washington Department of Biostatistics

Categories

Histopathology, Melanoma, Dermatopathology, Melanocytic Proliferation, Pathology of Melanoma, Diagnostic Accuracy

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