Lipidomics and proteomics data from STGD1 mouse model and patient-derived iPSC-RPE cells

Description

This repository contains datasets associated with the manuscript titled “DGAT1-Mediated Lipid–Retinoid Buildup Causes Metabolic Impairment in the RPE of Stargardt Disease.” The repository includes three sets of raw and processed data: (1) Lipidomics data from 3- and 4- month-old Wild-type and Abca4 knockout mice neural retina and retinal pigment epithelium. (2) Lipidomics data from 2.5- and 7-month in culture normal and Stargardt patient (H)- iPSC RPE. (3) Proteomics data from 6- month-old Wild-type and Abca4 knockout mice retinal pigment epithelium.

Steps to reproduce

All experimental procedures and data analysis details required to reproduce the findings are described in the manuscript “DGAT1-Mediated Lipid–Retinoid Buildup Causes Metabolic Impairment in the RPE of Stargardt Disease.” Please refer to the methods section of the manuscript.

Institutions

• University of California, Los Angeles

  California, Los Angeles

Categories

Funders

• National Eye Institute

  Maryland, Bethesda

  Grant ID: EY025002
• Research to Prevent Blindness

  New York, New York

  Grant ID: NA
• National Eye Institute

  Maryland, Bethesda

  Grant ID: EY000331
• Eli and Edythe Broad Foundation

  California, Los Angeles

  Grant ID: Rose Hills Foundation Innovator Grant

Licence