TBI and traumatic endotheliopathy

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Hypothesis: head injury can lead to EoT and that the presence of severe TBI in combination with polytrauma potentiates glycocalyx breakdown. We expected that patients with both TBI and polytrauma would more frequently have EoT than would patients with either TBI alone or polytrauma alone. 1. Aim 1: To determine the frequency of EoT in TBI patients. 2. Aim 2: to evaluate how the breakdown of the glycocalyx and the presence of EoT affect outcome in the context of TBI. Prospective observational study. Main biomarker: syndecan-1 Other EoT biomarkers: sTM, adrenaline, noradrenaline. EoT= syndecan-1 >40 ng/ml

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