Data for: Synaptic remodeling and reduced expression of the transcription factors, HES1 and HES5, in the cortex neurons of cognitively impaired hyperhomocysteinemic mice

Published: 25 April 2020| Version 1 | DOI: 10.17632/swfygy4z2f.1
Jianzhong Zhang, Li Jing, Yili Wang, Yan-Mei Ma, Jing-Wen Zhang


This study aims to clarify the relationship between cognitive dysfunction and hyperhomocysteinemia (HHcy) in mice. Although this relationship has been frequently observed in previous studies, the molecular mechanisms underpinning cognitive impairment during HHcy remain unclear. HHcy is a common metabolic disorder in humans, and the results of the present study may support better clinical decision making in cases where cognitive impairment has been diagnosed. Here, we present evidence that mice with induced HHcy have increased autophagy, apoptosis, synaptic remodeling, and downregulation of Hes1 and Hes5 in their brains compared to those of control mice. This supports the theory that HHcy-mediated remodeling of the brain causes cognitive dysfunction.