Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease

Published: 24 July 2023| Version 2 | DOI: 10.17632/t4pphrvfzy.2
Contributor:
治杰

Description

To better understand the relationship between peripheral blood leukocyte and brain-based epigenetic activity in the context of Alzheimer's disease (AD) and Parkinson's disease (PD), we conducted a pilot study on peripheral blood leukocytes by comprehensively analysing transcriptomic and metabolic features in blood (NCONTROL = 15; NAD = 11; PD = 13). Using next-generation sequencing, we identified 766 miRNAs and 19,512 mRNAs/lncRNAs after removing low-quality reads and low-abundance RNAs. Using LC-MS/MS, we identified 8 DE metabolites of 7 short-chain fatty acids and 23 neurotransmitters. Using a comprehensive integrative analysis of multi-omics data, we identified an ADARB1-centred co-expression sub-network consisting of ADARB1, LINC02960 and 109 miRNAs simultaneously correlated with diagnosis, glutamate and phenethylamine. A putative interaction within the ADARB1 module was raised in the blood ecosystem of AD and PD.

Files

Institutions

University of the Chinese Academy of Sciences

Categories

Neurodegenerative Disorder, Omics

Funding

the Science, Technology and Innovation Commission of Shenzhen Municipality

JCYJ20180507183615145

Licence