β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4 in vascular cells
Published: 22 August 2019| Version 4 | DOI: 10.17632/t57mvdfz39.4
β-Hydroxybutyrate prevents vascular cell senescence via inducing cell quiescence. β-Hydroxybutyrate- mediated vascular cell quiescence is dependent on Oct4 expression, which is upregulated by forming hnRNP A1 complex with Oct4 mRNAs. β-Hydroxybutyrate-induced Oct4 expression is negatively correlated with hallmarks of senescence in vivo.
Georgia State University
Aging, Cellular Senescence, Ketones