β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4 in vascular cells

Published: 22 August 2019| Version 4 | DOI: 10.17632/t57mvdfz39.4
Contributor:
Young-min Han

Description

β-Hydroxybutyrate prevents vascular cell senescence via inducing cell quiescence. β-Hydroxybutyrate- mediated vascular cell quiescence is dependent on Oct4 expression, which is upregulated by forming hnRNP A1 complex with Oct4 mRNAs. β-Hydroxybutyrate-induced Oct4 expression is negatively correlated with hallmarks of senescence in vivo.

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