MHC Ligandomes of Reovirus-Treated Tumors

Published: 23-04-2019| Version 2 | DOI: 10.17632/t5xb48z959.2
Contributor:
John Patrick Murphy

Description

Using a mass spectrometry (MS)-based MHC-I ligandome discovery platform, we determined differential tumor MHC-I ligand expression following treatment with oncolytic reovirus in a murine ovarian cancer model. We then tested the immunogenicity and antitumor immune effects of CD8 T cells specific to these reovirus-induced ligands.

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