Impact of PCV10 on nasopharyngeal carriage in children in Pakistan

Published: 20 January 2021| Version 1 | DOI: 10.17632/t79h6g97gr.1
Contributor:
Muhammad Imran Nisar

Description

This data set is from the study "Direct and indirect effect of 10 valent pneumococcal vaccines on the nasopharyngeal carriage in children under 2 years of age in Matiari, Pakistan" published in the journal Vaccine which can be accessed from Nisar MI, Ahmed S, Jehan F, Shahid S, Shakoor S, Kabir F, Hotwani A, Munir S, Muhammad S, Khalid F, Althouse B, Hu H, Whitney C, Rodgers G, Klugman K, Ali A, Zaidi AKM, Omer SB, Iqbal N. Direct and indirect effect of 10 valent pneumococcal vaccines on the nasopharyngeal carriage in children under 2 years of age in Matiari, Pakistan. Vaccine. 2021 Jan 6:S0264-410X(20)31662-5. DOI: 10.1016/j.vaccine.2020.12.066. Epub ahead of print. PMID: 33422379. Data was collected for a time-series cross-sectional study exploring the impact of 10-valent Pneumococcal Conjugate Vaccine (PCV10) on nasopharyngeal (NP) carriage in children under 2 years of age from a rural population in Sindh, Pakistan. The study was carried out in two union councils of Matiari - Khyber and Shah Alam Shah Jee Wasi (Latitude 25.680298 / Longitude 68.502711). Data was collected on socio-demographics, clinical characteristics, and vaccination status using an android phone-based application. NP samples were collected using standard World Health Organisation (WHO) techniques, culture and serotyping were done using sequential Multiplex PCR described by the Centre for Disease Control, USA. We looked at the carriage rate of vaccine-type (VT) and non-vaccine type (NVT) serotypes over time in vaccinated and unvaccinated children. We additionally looked at the predictors for pneumococcal carriage. The study showed a high overall pneumococcal carriage in a large sample of 3140 children enrolled from a rural setting in Pakistan over a period of four years. Vaccine type carriage decreased both in the vaccinated and unvaccinated population indicating herd immunity.

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